International Circulation: How successful is the Working Group in building collaborations?
　　Dr van de Borne: It works pretty well. The point is that every time there is a new field of investigation， there is more data to generate and new topics that are not well known. Once the Working Group has several years of activity， and my Working Group has been a long-term Working Group， then there are less new ideas and less new things to look at. I think the right way to move then is to exchange ideas with other Working Groups so you can build on new interactions and new ideas and continue generating new data.
　　International Circulation: I think it is interesting that you are going to merge with the Ambulatory Blood Pressure Group.
　　Dr van de Borne: We are the only group doing that at least at this time. I think this is a new trend that will empower the Groups and maybe having less Working Groups means they can be even more active than they were before.
　　International Circulation: Recently what I hear about is variability within a 24-hour period and also visit-to-visit variability. I don’t hear very much about beat-to-beat variability.
　　Dr van de Borne: That is the point of us getting together. Beat-to-beat variability is very interesting from a physiological point of view. It is very nice to try and understand why blood pressure is changing from one beat to another but it is very difficult to show that this has an important clinical significance. The physiology behind it is superb and there are also a lot of bioengineers interested in the analysis of variation. There is a lot of autonomic background behind being asleep， being awake， dreaming and so on. Diseases also affect it. But to be able to show that this has a clinical impact is very difficult and also there is no specific therapy that will change beat-to-beat blood pressure variability. So as I said the pathophysiology is nice but the clinical implications are a little less obvious.
　　《国际循环》：工作组在建立科研合作方面取得了哪些成绩？
　　Dr van de Borne： 工作组在这方面做的非常好。重点是每次出现一个新的研究领域，就会产生更多的数据和有待继续探索的新主题。一旦工作组有了几年的工作经验，就像我们工作组已经开展了很多年的工作，那么新的想法就会更少，能探索的新东西也就更少。我认为继续前进的最好办法是和其他工作组交换意见以便于能建立新联系和产生新的想法并继续得到新的数据。
　　《国际循环》：我认为有趣的是你们将和动态血压工作组合并。
　　Dr van de Borne： 至少在目前我们是唯一进行这项工作的组织。我认为这是一个增强工作组功能的新趋势并且可能工作组越少就意味着他们会比以前更有活力。
　　《国际循环》：最近我听到谈论的是关于24小时内的变异性和每次就诊变异性。我并没有听到太多的谈论关注每搏变异性。
　　Dr van de Borne： 这就是我们合并的工作重点。从生理的角度来讲每搏变异性非常有意思。尝试理解为何血压在每搏都发生变化很有意义，但是很难显示每搏变异性有很重要的临床意义。它背后的生理意义很重要并且已经有很多生物工程学家致力于分析这种变异。睡觉，清醒，做梦以及其它很多都是这种变异性的自律背景。疾病也同样影响着它。但是要想显示这种变异性的临床意义是很难的并且没有特殊的治疗方法来改变每搏血压变异性。因此我说每搏变异性的病理生理意义是很好的但是临床意义不容易被观察到。